The actor, 65, turned and yelled at the crowd to ‘back the f**k off’ after he and Rita Wilson, 65, were mobbed outside a restaurant in Midtown.
The shocking moment comes amid ongoing concerns regarding Tom’s health after he was filmed visibly shaking and unable to control his arm earlier this month.
As the pair left the eatery a large crowd formed and swarmed towards them, with one member of the public getting too close and knocking Rita, causing her to lose her footing.
As she wobbled on her feet and tried to regain her composure she shouted ‘stop it!’ and held up her hands.
Back the f**k off!’: Tom Hanks rushed to protect his wife Rita Wilson in New York on Wednesday after an aggressive fans nearly knocked her over
After rushing to see if Rita was ok, Tom then turned to the crowds and yelled, ‘my wife? Back the f**k up! Knocking over my wife?!’ before the couple quickly ran into a waiting car.
While Tom did not respond, a sheepish fan shouted out ‘sorry about that Tom’ as the couple sped off.
Tom and Rita have been married for 34 years and have two sons, Chet, 31, and Truman, 25. They first met on the set of ABC’s sitcom Bosom Buddies in 1981 and became friends before their relationship turned romantic.
The couple had grabbed dinner together after attending a screening of Elvis earlier in the evening. Tom has been kept busy on the promotional trail for the upcoming Presley biopic in which he plays Colonel Tom Parker, Elvis’ manager.
Scary: The actor, 65, was quick to defend Rita Wilson, 65, from the crowds after overenthusiastic fans mobbed the couple outside a restaurant in Midtown ‘
Shock: After rushing to see if Rita was ok, Tom then turned to the crowds and said ‘my wife? Back the f**k up! Knocking over my wife?!’ before the couple quickly ran into a waiting car
Earlier in the afternoon Tom displayed his gaunt frame in a baggy T-shirt and baseball cap as he headed out on a solo stroll around Manhattan amid concerns over his health.
Fears were sparked when he seemed unable to control shaking in his arm during a promotional junket for his new film, Elvis.
He appeared at a screening in Brisbane alongside director Baz Luhrmann and co-star Austin Butler earlier this month and his arm visibly shook as he spoke.
‘There is no better place in the world to make a motion picture than right here on the Gold Coast,’ he said, microphone in his right hand, and left hand in his pocket.
The actor has famously shed the pounds for movies in the past, including his role as a desert island dweller in Castaway, and dying AIDS sufferer in Philadelphia.
Tom is known for his grueling preparations for his films, and it was unclear whether he recent weight loss was for a new role.
Cute couple: Tom and Rita have been married for 34 years and have two sons, Chet, 31, and Truman, 25 (pictured in 2020)
His next scheduled film is the Robert Zemeckis-directed Here, which he will star in alongside Robin Wright.
‘Set in one single room, follows the many people who inhabit it over years and years, from the past to the future,’ the film’s synopsis on IMDB reads.
Tom’s most dramatic weight loss was for Castaway in 2000, when he shed 50lbs, and in the 1993 film Philadelphia, for which he lost 35lbs.
He has also packed on the pounds – most notably for the 1992 film A League of Their Own, when he gained 30lbs.
In 2013, Tom revealed he had been diagnosed with type 2 diabetes, which he said was down to being ‘lazy’ and ‘an idiot’.
Out and about: The dinner date came hours after he displayed his gaunt frame on a solo stroll around Manhattan amid concerns over the actor’s health
He told the then-Late Show host David Letterman: ‘I went to the doctor, and he said, ‘You know those high blood sugar numbers you’ve been dealing with since you were 36? Well, you’ve graduated! You’ve got type 2 diabetes, young man.”
The beloved actor’s shaking led one doctor to tell DailyMail.com it could be an early sign of Parkinson’s.
Dr Stuart Fischer, a Yale University graduate with four years’ experience in emergency medicine, who is now the medical director of two nursing homes in New York City, said the Australia footage suggested the degenerative disease.
‘Parkinson’s would be uppermost in most physicians minds,’ he told DailyMail.com, after viewing the footage.
‘This trembling hand can be an early sign of the disease. One would think he would be on the path to a neurologists office now if not already.
‘It could be weeks, months or years before it progresses. It could be like with the famous conductor James Levine, it did take many years for a leg tremor to evolve into a bodily manifestation.’
Concerns: Tom appeared at a Elvis screening in Brisbane alongside director Baz Luhrmann and co-star Austin Butler earlier this month and his arm visibly shook as he spoke
He said the shaking could be tremors, but given Tom’s age it was unlikely.
‘The other condition it could be is an essential tremor, but this usually occurs at a younger age – although it can be worsened by anxiety and stress,’ he said. ‘It usually affects people in their 20s and 30s.’
Asked if it could be linked to Tom’s diabetes, he said: ‘No link to type 2 diabetes. I’ve never heard of that at all.’
He also ruled out it being linked to Tom previously having COVID.
Robert H. Eckel, board member of the American Diabetes Association and a past president of the American Heart Association, told DailyMail.com that, in general, people with diabetes could shake if their blood sugar got too low.
Tom’s representatives are yet to respond to DailyMail.com’s request for comment.
One to watch: Tom plays Tom Parker, Elvis’s manager, in the Elvis biopic, with Austin Butler starring as Elvis Presley
In several television appearances to promote the Elvis film, Tom is noticeably keeping his hands clasped together for much of the time.
On June 13, Tom and his co-star Austin appeared on GMA, talking to the hosts from Graceland after a special screening for the Presley family.
On May 31 the pair were in London, and spoke to BBC’s The One Show. In Australia, earlier this month, the crowd were lapping up his tales of filming in their city.
‘I’ve shot films in Morocco and Los Angeles and New York City and Seattle and in Berlin.
‘None of them have what the Gold Coast have, and what is that? Two words. None of those other cities have Dan Murphy,’ he said, referencing the chain of liquor stores, Dan Murphy’s.
‘What a man, who I got to know quite well,’ he said, to applause.
Keeping close: In several television appearances to promote the Elvis film, Tom is noticeably keeping his hands clasped together for much of the time (pictured on The One Show on May 31)
As his hand shook, Tom tried to control it, by placing his left hand at the bottom of the microphone, below his right. He also attempted briefly to switch hands.
The audience did not appear to notice, however, as Tom delighted them by declaring: ‘We had an absolutely magnificent time with you all.
‘There is something about the people and the place of the Gold Coast that makes everyone walk around with a confident look on their face. We were a part of that.
‘Your confidence, joy and zest for life comes through in our motion picture.’
He added: ‘You have a wonderful proactive golden son in Baz Luhrmann who loves Australia more than kangaroos, more than Dan Murphy.’
Tom famously played a Second World War soldier with PTSD in Saving Private Ryan, whose hands visibly shook due to the immense stress he had endured.
At one point, Tom’s character, Captain Miller, tells Sergeant Horvath that the shaking ‘comes and goes.’
Horvath replies: ‘You may have to get yourself a new line of work. This one doesn’t seem to agree with you anymore.’
PTSD: Tom famously played a Second World War soldier with PTSD in Saving Private Ryan, whose hands visibly shook due to the immense stress he had endured
Following the Australian premier, Toms flew back to the United States, where the film was screened at Graceland on June 11.
‘The only reason I’m here, it’s been done right,’ said Lisa Marie Presley, praising Luhrmann’s and Butler’s interpretations of her father’s story.
‘I was quite young, but I still remember my father’s energy and his vibe. And Austin, he — what’s the word? — he nailed it.’
She said Butler’s success in the role was a contrast to previous attempts at Elvis onscreen.
‘In my life, it’s been one disappointment after another, in terms of people portraying my father. Bless their hearts, I’m sure they meant well.’
Elvis cast: Tom is seen on June 13 at Graceland with (from left): Olivia De Jonge, who plays Priscilla; Austin Butler, director Baz Luhrmann, and SiriusXm host Jess Cagle